Abstract
We purified a novel substance with survival activity for spinal motoneurons from skeletal muscles of chick embryos. The purification procedure using various column chromatographies was described. The purified substance showed a maximum UV absorbance at 258nm, which suggests that it is non-peptidergic in nature. This is the first report to show that a non-peptidergic substance exhibits the survival activity on spinal motoneurons. A possible candidate for the substance was discussed.
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Schedule a callMore From: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
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