Abstract
We have demonstrated the existence of a peptide-like opioid in bovine and porcine pituitary, and determined some of its properties. It is an opioid agonist on the guinea pig myenteric plexus-longitudinal muscle preparation, and on the mouse vas deferens, and it binds to opiate receptors in homogenates of guinea pig brain. Its physiologic role and its possible presence in hypothalamic or other brain regions remain to be determined.
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