Abstract
Entamoeba histolytica is responsible for human invasive amebiasis. This disease has an endemic behavior in specific geographic areas throughout the world, and is commonly associated with population with low socioeconomic and educational conditions (1). It is in these endemic areas where the evaluation of prevalence of infection and disease through the detection of antiameba antibodies in serum and secretions is particularly valuable. Although there is an increasing number of new strategies to make available better antibody and antigen detection tests (2), the complexity of data analysis obtained in epidemiologic trials in highly endemic areas justifies the search for new antigens of E. histolytica with biological or molecular characteristics that may optimize antibody detection tests for use in field studies. In the present article, we describe the purification of three proteases of E. histolytica HM-1:IMSS that previously showed to be highly recognized (91.4%) by serum antibodies from patients with amebic dysentery (3), and in more than 95% of amebic liver abscess patients. Preliminary data suggest that antibody levels to these proteins decrease significantly after 6 months of treatment, which makes them attractive for the detection of new cases of invasive amebic disease.
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