Pure prostatic ductal adenocarcinoma with elevated prostate-specific antigen level: a rare case report and literature review

Abstract

Introduction: Prostatic ductal adenocarcinoma (PDA) is rare, representing approximately 0.4 to 0.8% of all prostate malignancies. It usually occurs in the prostatic urethra around verumontanum, its prognosis is generally considered to be worse compared to acinar adenocarcinoma.Case description: We present a 75-year-old male with PDA with an elevated PSA level. PDA histologically characterized by pseudostratified columnar cells. It is associated with aggressive behavior with an overall poor prognosis. Although normal PSA is a common finding in those with PDA, the presence of elevated PSA levels should not be used to exclude the possibility of PDA.Conclusion: PDA is a rare variant of prostate cancer which is histologically characterized by pseudostratified columnar cells. Although normal PSA is a frequent finding in those with PDA, the presence of elevated PSA should not be used to exclude the possibility of PDA.