Abstract
This study aimed to evaluate the effect of two platelet preparations used in the clinic, pure platelet-rich plasma (P-PRP) and the supernatant of calcium-activated P-PRP (S-PRP), on the phenotype of human macrophages. Surface markers and cytokine production of human monocyte-derived macrophages were analyzed after 24h stimulation with P-PRP or S-PRP. P-PRP and S-PRP present no difference in the expression of CD206, a M2 tissue-repair macrophage-related marker. However, these same macrophages presented different levels of CD163, CD86 as well as different IL-10 secretion capacities after 24h incubation. These platelet preparations do not have an equivalent biological effect over macrophages, which suggest that they may present different clinical regenerative potentials.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have