Abstract
Significantly more male mice castrated at birth killed newborn pups in response to adult testosterone propionate (TP) treatment than sham-operated controls. Female mice administered TP or estradiol benzoate (EB), but not testosterone (T), dihydrotestosterone (DHT), or dihydrotestosterone propionate (DHTP), on the day of birth killed significantly fewer young in response to adult TP than oil-treated controls. Neonatal MER-25 treatment prevented the suppressive effects of early TP exposure on T aroused pup-killing behavior. These data show that early androgen exposure attenuates the pup-killing producing properties of adult T and that aromatization of T to estrogen (E) during early life may mediate these effects.
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