Pupillary responses and attentional allocation problems on the backward masking task in schizophrenia

Abstract

Early visual information processing impairment has consistently been found on the backward masking task in patients with schizophrenia, but the nature of this impairment remains unclear. Pupillometry was used to measure attentional allocation during visual backward masking task performance in patients with schizophrenia ( n=16) and nonpsychiatric controls ( n=16). The extent of pupil dilation recorded during a cognitive task reflects the processing load placed on the nervous system by the task. Schizophrenia patients detected significantly fewer targets than controls only when the stimulus onset asynchrony (SOA) between targets and masks reached 317 ms. For both groups, peak pupil dilation responses were also significantly larger in the 317 ms SOA condition relative to a no-mask condition, suggesting that the processing load of the 317 SOA masking condition was greater than the no-mask condition. In addition, a principal components analysis of pupillary response waveforms identified time-related factors that appeared to differentially index attentional allocation to targets vs. masks. Patients with schizophrenia showed less dilation than controls on a middle factor that appeared to index attentional allocation to targets, but patients showed greater dilation than controls on a late factor that appeared to index attentional allocation to masks. That is, controls attended more to targets than to masks, but patients attended more to masks than to targets. These findings suggest that masking impairments at SOA intervals greater than 100–200 ms may be due abnormalities in attentional allocation mechanisms.