Abstract
Ketene dithioacetal monoxides (KDMs) bring out a variety of latent intriguing reactivity upon treatment with triflic anhydride. The extended Pummerer reactions of KDMs provide reliable accesses to heteroaromatic compounds including (benzo) furan, (benzo) thiophene, and pyrroles. Trifluoromethyl-substituted KDMs are useful building blocks to prepare α-trifluoromethyl carbonyl compounds and 3-trifluoromethyl heteroaromatic compounds. A newly uncovered interrupted Pummerer reaction/[3,3]sigmatropic rearrangement cascade is the key that realizes most of the transformations in this paper. The last part of this paper describes the first example of metal-catalyzed Pummerer reaction where sulfoxides are directly activated by the catalyst.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
