Abstract
Hypertension is a major risk factor for cardiovascular disease and thus at the origin of many deaths by e.g. heart attack or stroke. Hypertension is caused by many factors including an increase in arterial stiffness which leads to changes in pulse wave velocity and wave reflections. Those often result in an increased left ventricular load which may result in heart failure as well as an increased pulsatile pressure in the microcirculation l to damage to blood vessels. In order to specifically treat the different causes of hypertension it is desirable to perform a pulse wave analysis as a complement to measurements of systolic and diastolic pressure by brachial cuff sphygmomanometry. Here we show that Diffusing Wave Spectroscopy, a novel non-invasive portable tool, is able to monitor blood flow changes with a high temporal resolution. The measured pulse travel times give detailed information of the pulse wave blood flow profile.
Highlights
Hypertension is a major risk factor for cardiovascular (CV) disease and to the development of many deaths by e.g. heart attack or stroke
Diffusing wave spectroscopy measurements were performed with a fiber-multispeckle setup described earlier [8]
For the carotid artery the average shape of the diffusion coefficient in the diffusion only model and mixed diffusion shearing model differs in that the first peak (P1) is delayed in the second case and there is only a shoulder compared to a second peak (P2) in the diffusion model
Summary
Hypertension is a major risk factor for cardiovascular (CV) disease and to the development of many deaths by e.g. heart attack or stroke. Arterial stiffness which has an independent predictive value for cardiovascular events [1] and is suggested as a complement of systolic and diastolic pressure by brachial cuff sphygmomanometry [2] is usually not considered. In the case of stiff arteries the PWV rises and the reflected wave turns back earlier, adding to the forward wave and augmenting the systolic pressure [1]. This requires higher central pulse pressure and an increased systolic pressure which leads to an increased left ventricular load and a higher oxygen demand [1]. A direct measurement of the detailed temporal shape of the pulse is desirable
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