Pulse on Stroke in Pulseless Disease (Takayasu Arteritis).

Abstract

HomeStrokeVol. 53, No. 5Pulse on Stroke in Pulseless Disease (Takayasu Arteritis) Free AccessEditorialPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyRedditDiggEmail Jump toFree AccessEditorialPDF/EPUBPulse on Stroke in Pulseless Disease (Takayasu Arteritis) Alexis T. Roy, MD, MSc and Aneesh B. Singhal, MD Alexis T. RoyAlexis T. Roy Department of Neurology (Stroke Division), Massachusetts General Hospital, Boston. Search for more papers by this author and Aneesh B. SinghalAneesh B. Singhal Correspondence to: Aneesh B. Singhal, MD, Department of Neurology, ACC-729-C, Massachusetts General Hospital, Boston, MA 02114. Email E-mail Address: [email protected] https://orcid.org/0000-0002-2641-5277 Department of Neurology (Stroke Division), Massachusetts General Hospital, Boston. Search for more papers by this author Originally published31 Mar 2022https://doi.org/10.1161/STROKEAHA.121.036596Stroke. 2022;53:1558–1559This article is a commentary on the followingCerebrovascular Ischemic Events in Patients With Takayasu ArteritisOther version(s) of this articleYou are viewing the most recent version of this article. Previous versions: March 31, 2022: Ahead of Print See related article, p 1550Takayasu arteritis, first described during an ophthalmology meeting in 1908, is a rare and chronic systemic vasculitis of unknown mechanism mainly involving the aorta, its major branches, and the retinal arteries.1,2 Pathologically, it is a pan-arteritis with fibrous thickening and destruction of all layers of the artery, and cellular infiltration around the vasa vasorum. Young women are predominantly affected. The disease is more prevalent in Asia (especially Japan) and Latin America as compared to Western countries. Obstruction of the subclavian or brachial arteries frequently results in loss of the radial pulse (hence the name ‘pulseless disease’). Ischemic symptoms in the brain, retina, and other organs result from arterial stenosis or thrombus formation and rarely dissection or aneurysmal rupture.Prior studies have shown a high prevalence of stroke in Takayasu arteritis, and a substantial proportion develop stroke as its first manifestation.3,4 Knowledge about stroke presentations, risk factors, recurrence, and prevention in Takayasu arteritis has been lacking. To address this, the French Takayasu Network conducted a retrospective analysis of 320 patients with Takayasu arteritis encountered over nearly 45 years (1970–2014) in multiple referral centers.5 Strengths of the study include the large number of patients with this rare disease, the use of accepted diagnostic criteria, the detailed pictorial depiction of affected arteries and stroke territories involved, treatment information, and long follow-up. In this study, 13% developed ischemic stroke and 7% developed transient ischemic attack (TIA) at the time of diagnosis or during follow-up. This may be an underestimate since 75% of stroke/TIA patients were diagnosed after the year 2000, and their diagnosis was based on imaging which has evolved and is not available in the initial study years. Stroke/TIA occurred before the eventual diagnosis of Takayasu arteritis in 60%, showing how important it is to palpate arterial pulses, look for blood pressure differences between arms, do a funduscopic examination, and consider tests for vasculitis in young individuals with stroke.The vast majority of stroke/TIA involved the anterior circulation. No patient developed brain hemorrhage. Interestingly, carotidynia symptoms and prolonged time to diagnosis but not intuitive risk factors, such as supra-aortic involvement, degree of stenosis or intracranial artery involvement, or atherosclerosis risk factors, were associated with stroke/TIA. Hence the authors postulate that alternative mechanisms such as microvascular involvement may also contribute to cerebrovascular events.6 Further studies utilizing perfusion-magnetic resonance imaging and positron emission tomography scans are warranted to fully understand mechanisms of stroke in Takayasu arteritis. Of course, the study was likely underpowered, and the results are likely confounded by the more frequent use of stroke preventive medications such as aspirin, clopidogrel, and anticoagulants in patients considered high risk due to widespread arterial involvement, and the inclusion of TIA (a less reliable outcome versus imaging-confirmed stroke) in the analysis.Over half the patients had recurrent stroke. It is sobering that there was no difference in stroke-free survival between patients diagnosed before and after 2000 despite medical advancements. Delayed diagnosis increased the risk for stroke recurrence, emphasizing the ongoing challenges in diagnosing cerebral arteriopathies.7 Although this study provides important information about stroke in Takayasu arteritis, prospective multicenter collaborative studies—similar to ongoing efforts concerning stroke in young adults and rare causes of stroke such as primary central nervous system vasculitis—are urgently needed to fully understand its mechanisms, risk factors, and develop evidence-based treatment strategies.8,9 After all, although uncommon, Takayasu arteritis affects young patients where the occurrence of stroke and even TIA carries a disproportionately high socio-economic and psychological impact.10–12Article InformationDisclosures Dr Singhal reports compensation from Medlink for other services; other intellectual property licensed to UptoDate Medicine; grants U10 NS086729, U01NS095869 from National Institutes of Health (NIH) Clinical Center; and compensation from Medicolegal Expert for expert witness services.FootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.For Disclosures, see page 1559.Correspondence to: Aneesh B. Singhal, MD, Department of Neurology, ACC-729-C, Massachusetts General Hospital, Boston, MA 02114. Email [email protected]harvard.edu