Abstract

Electrical stimulation of the septal or the lateral hypothalamic region was used to reinforce responding of rats. Holding constant the number, duration, and intensity of the pulses in each stimulation train, the pulse frequency was varied. Septal self-stimulation was found to be relatively invariant when every response was reinforced but was sensitive to frequency manipulations when variable interval reinforcement schedules were used. Septal self-stimulators responded most rapidly for low pulse frequencies (50/sec), while hypothalamic rats responded most rapidly for higher frequencies (250–400/sec). The frequency functions are not well accounted for by refractory period data, but do seem to represent fundamental differences in the neural substrates of reinforcement for these loci.

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