Abstract
The pulsatile secretion of luteinizing hormone (LH) was studied in adolescents with oligomenorrhea associated with hyperandrogenism (HA), and in a control group with regular cycles and normal androgen concentrations. Both groups consisted of six subjects, 15–18 years of age. Blood specimens were taken at 15 minute intervals for 6 hours. The mean serum LH concentration, amplitude and number of LH pulses, and the LH/FSH (follicle-stimulating hormone) ratio were significantly higher in the HA group than in the control group. Serum concentrations of androstenedione, testosterone, and estrone displayed significant positive correlations with the mean LH concentration, amplitude, and number of LH pulses, whereas serum dehydroepiandrosterone-sulfate (DHEA-S) and estradiol concentrations did not show any significant correlations with the characteristics of LH secretion. Thus, adolescents with hyperandrogenism display an exaggerated LH pulsatility similar to that found in adults with the polycystic ovary syndrome, and the change in LH pattern may be an early event in the development of this syndrome.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
