Abstract
The diseases involve heart and blood vessels are classified under cardiovascular diseases. Hypertension (HTN) is a disorder of the CV system characterized by elevated arterial blood pressure. Pulsatile drug delivery systems are on highlight today. This is due to their distinct advantage of releasing drug as the circadian rhythm of the disease. The beta-blockers are first-line therapy for the HTN. Hence, researches related to such modified formulations of these drugs are of need to increase the patient compliance and convenience. This review describes the various such systems published in literature. This also includes a brief description about circadian rhythm and beta-blockers. The researchers involved in the development of modified release formulations are the main target audience for this review.
Highlights
Cardiovascular diseases (CVD) are the leading cause of death globally, representing ~30% of all mortality [1]
HTN is a disorder of the CV system characterized by elevated arterial blood pressure (BP)
The swelling layer is composed of croscarmellose sodium, a super disintegrant and microcrystalline cellulose (MCC) as a diluent, while the rupturable coating is Ethylcellulose [39]
Summary
Cardiovascular diseases (CVD) are the leading cause of death globally, representing ~30% of all mortality [1]. Another floating pulsatile delivery system consisted of three different parts: A core tablet, containing the active ingredient, an erodible outer shell, and a top cover buoyant layer. Core tablets (6 mm) containing carvedilol and 10-mm press-coated tablets were prepared [47] by direct compression using different concentrations of rate-controlling polymers.
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