Abstract
Rapid-time confocal scanning has demonstrated that neutrophils undergoing CD11b/CD18 integrin-dependent adhesion show repeated elevations in cytosolic free Ca2+concentration, due to Ca2+influx. The magnitude of each individual influx, compared to the previous one, depended upon the time between the two, and not upon the cytosolic Ca2+concentration at the start of the influx. Influx events occurring less than 100 seconds after the previous Ca2+rise were observed not to reach the concentration of the preceding peak, whilst events occurring later usually exceeded the magnitude of the previous Ca2+concentration. This suggested temporary inactivation, followed by recovery, of the Ca2+influx mechanism. In addition, Ca2+influx was most likely to occur immediately following this recovery. The involvement of Ca2+store release at the site of integrin engagement suggested that the cytoskeletal connection between the peripheral store and membrane was facilitating the signalling of Ca2+influx.
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