Pulsatile blood flow simulations of magnetic drug targeting (MDT) for drug particles dispersion through stenosis asymmetric and symmetric vessels

Abstract

Magnetic drug delivery has emerged as an innovative strategy for addressing medical conditions like tumors and vascular occlusions. In this study, we delve into the influence of magnetic fields on three-dimensional models representing various vessel configurations, including unobstructed, asymmetric, and symmetric vessels. We take into account critical factors such as non-Newtonian viscosity, pulsatile flow, and the presence of vessel obstructions. By investigating drug particles ranging from 1 to 4 µm in diameter, our findings illuminate the central role that magnetic particles play in Magnetic Drug Targeting (MDT). Importantly, we observe a substantial enhancement in drug particle capture efficiency in the presence of a magnetic field, particularly for larger particle diameters. Nevertheless, this efficiency saturates at 100% for diameters exceeding 3 µm due to particle–wall interactions. Interestingly, within potential obstruction areas, particle capture efficiency exhibits a nuanced relationship with diameter. Even at a diameter of 4 µm, the magnetic field's influence on vessel walls leads to particle capture before reaching obstructions, thus reducing efficiency. Comparing scenarios without a magnetic field, it is found that symmetrical obstructions yield higher capture efficiency compared to asymmetrical vessels, and asymmetric vessels outperform their smoother counterparts. Moreover, the presence of vessel obstructions amplifies drug particle capture efficiency. Consequently, our simulations unveil significant potential for the application of MDT in the treatment of atherosclerosis. From a physics perspective, these results offer promising prospects for the application of Magnetic Drug Targeting in the realm of cardiovascular diseases.