Pulpotomy in human deciduous teeth and bone morphogenetic protein ( rhBMP-2)

Abstract

Recent studies of pulpotomy and direct pulp capping using bone morphogenetic protein (BMP) in the teeth of animals have indicated a role for BMP in the induction and biological production of dentin. The aim of this study was to observe painful reactions and signs of clinical and radiographic pathological alterations in human deciduous teeth, as well as to histologically examine pulp tissue after the use of recombinant human BMP-2 in a collagen scaffold. MATERIAL AND METHOD: Five deciduous teeth for which pulpotomy had been indicated were studied. rhBMP-2 was placed in the pulp chamber of the teeth, and they were then filled using composite resin. In two teeth that exfoliated, histological examinations were performed. RESULTS: After twelve months, we observed 100% clinical and radiographic success, with no detectable abnormalities. On the histological sections, areas of inflammation, pulp necrosis and internal reabsorption, as well as the formation of tissue resembling osteodentin in the radicular portion, were observed. CONCLUSIONS: It could be concluded that the absence of symptomatology and clinical and radiographic alterations suggests that rhBMP-2 is a material with inductive properties that should be further investigated for use as an alternative to pulpotomy treatment