Pulp Response Capped by Brain Derived Neurotrophic Factor (BDNF)

Abstract

Background: Four neurotrophins (NTFs) are a family of structurally related proteins with specific effects on the developing nervous system and non-neuronal differentiating cells. The brain-derived neurotrophic factor ( BDNF) has role in differentiation of pulp cells into mineralizing cells,and that was identified as survival factor , development and function of dental tissues.Aim of the study: The study was designed to illustrate pulp response capped by brain-derived neurotrophic factor after mechanical trauma.Materials and Method: Brain derived neurotrophic factor was used as pulp capped material for maxillary anterior teeth of (12 )rat following the mechanical traumatized proceduce.Pulp reaction was studied histologically from the first cutting procedure ,followed by interval periods (48,72,168 hours ) ,Six teeth for each period .Results: Illustrated an enhancement of pulp healing represented by newly apposition of reparative dentine with presences of active angiogenesis followed by globular minerlization that coincides with proceeding interval time.Conclusion: The study suggest that BDNF contributes in pulp healing and can be addressed to a more conservative treatment approach.