Abstract
Treatment of patients with Acute Lung Injury (ALI) can be challenging. Mechanical ventilation is often required and can have significant adverse cardiovascular effects. Clinicians and research scientists have been able to utilize an experimental model of ALI/Acute Respiratory Distress Syndrome (ARDS) that can mimic much of the clinical sequelae. This model has provided the opportunity to systematically test best care practices and clarify the important cardiopulmonary interaction during mechanical ventilation. During mechanical ventilation with positive end-expiratory pressure, increased pulmonary vascular resistance (PVR) may adversely affect right ventricular (RV) function, and therefore, left ventricular (LV) function. Thus, increased resistance to RV output can result in decreased LV preload by series interaction, but importantly, also by direct ventricular interaction (DVI) (leftward septal shift). Therefore, if the increase in PVR can be minimized, for example, by volume loading or nitric oxide, the adverse effects of mechanical ventilation on cardiac function may be limited. This paper will review the possible cardiac consequences of elevated PVR through DVI during mechanical ventilation in ALI, and suggest potential benefits of reducing PVR.
Highlights
Treatment of patients with Acute Lung Injury (ALI) can be challenging
Our results suggested that pulmonary vascular resistance (PVR) was closely related to right ventricular (RV) and left ventricular (LV) performance and volume loading, by reducing PVR, improved RV and, LV performance by series interaction and direct ventricular interaction (DVI) (the TSG increased, which implies that rightward septal shift (DVI) contributed to the increased LV preload)
Reducing PVR has the potential to improve cardiac function by several mechanisms resulting in improved RV systolic function and increased LV preload and output
Summary
Pulmonary Vascular Resistance and Direct Ventricular Interaction during Mechanical Ventilation in an Oleic Acid Induced Acute Lung Injury Model: A Review.
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