Pulmonary sequestration in adults: a retrospective review of resected and unresected cases

Mohammad Alsumrain,Jay H Ryu

doi:10.1186/s12890-018-0663-z

Mohammad Alsumrain, Jay H Ryu

Open Access

https://doi.org/10.1186/s12890-018-0663-z

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Journal: BMC Pulmonary Medicine	Publication Date: Jun 5, 2018
Citations: 42	License type: open-access

Affiliation: Mayo Clinic, Winneshiek Medical Center

Abstract

BackgroundPulmonary sequestration (PS) is a form of congenital pulmonary malformation that is generally diagnosed in childhood or adolescence and usually resected when diagnosed. We aim to identify the clinical presentation and course of patients diagnosed to have PS during adulthood.MethodsUsing a computer-assisted search of Mayo clinic medical records, we identified adult patients with PS diagnosed between 1997 and 2016. Clinical and radiological data were collected including postoperative course for those who underwent surgical resection.ResultsWe identified 32 adult patients with PS; median age at diagnosis was 42 years (IQR 28–53); 17 patients (53%) were men. The median sequestration size was 6.6 cm (IQR 4.4–9.3). The type of sequestration was intralobar in 81% and extralobar in 19%. The most common location was left lower lobe posteromedially (56%). Forty-seven percent of the patients presented with no relevant symptoms. The most common radiographic finding was mass/consolidation in 61% and the most common feeding artery origin was the thoracic aorta (54%). Surgical resection was performed in 18 patients (56%) and postoperative complication was reported in 5 patients (28%). There was no surgical mortality. Median duration of follow-up after diagnosis for unresected cases, most of whom were asymptomatic, was 19 months (IQR 4–26) with no complications related to the PS reported.ConclusionsNearly one-half of adult patients with PS present with no relevant symptoms. The decision regarding surgical resection needs to weigh various factors including clinical manifestations related to PS, risk of surgical complications, comorbidities, and individual patient preferences.

Highlights

Pulmonary sequestration (PS) is a form of congenital pulmonary malformation that is generally diagnosed in childhood or adolescence and usually resected when diagnosed
Pulmonary sequestration (PS) is a congenital lung malformation that consists of a nonfunctioning lung tissue with no apparent communication with the tracheobronchial tree [1]
The PS is divided into two types, intralobar sequestration (ILS) which is the more common type, where the lesion lies within pleural layer surrounding the lobar lung and extralobar sequestration (ELS) which has its own pleural covering, maintaining complete anatomic separation from adjacent normal lung [5]

Summary

Introduction

Pulmonary sequestration (PS) is a form of congenital pulmonary malformation that is generally diagnosed in childhood or adolescence and usually resected when diagnosed. We aim to identify the clinical presentation and course of patients diagnosed to have PS during adulthood. Pulmonary sequestration (PS) is a congenital lung malformation that consists of a nonfunctioning lung tissue with no apparent communication with the tracheobronchial tree [1]. PS is rare, representing about 1 to 6% of all congenital lung anomalies and may go undetected during the prenatal period and early childhood years [4]. Most patients with ILS present in adolescence or early adulthood with recurrent pneumonias in the affected lobe [4]. ELS rarely becomes infected because it is Alsumrain and Ryu BMC Pulmonary Medicine (2018) 18:97 separated from the tracheobronchial tree by its own pleural investment [4]

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