Abstract
BackgroundPulmonary sclerosing hemangioma (SH) is an uncommon tumor. The aim of this study was to identify the origin of pulmonary SH and summarize its clinicopathologic features.MethodsData of 26 cases of pulmonary SH were collected and reviewed, including their clinical symptoms, chest radiological examinations, treatments, and pathological findings.ResultsFemale patients of pulmonary SH were markedly frequent (n=23, 88.46%). Solitary mass or nodule in the lung fields was the most common manifestation (n=24, 92.31%), especially in the right middle lobe (n=9, 34.62%). There were two kinds of tumor cells: lining cells and round cells. All tumors contained a mixture of papillary, solid, sclerotic, and hemorrhagic patterns. Immunohistochemistry with a variable number of antibodies was performed for some cases. All of the detected specimens revealed strong reaction of lining cells with epithelial markers, such as thyroid transcription factor-1 (TTF-1), epithelial membrane antigen (EMA), cytokeratin (CK), pancytokeratin (PCK), and cytokeratin 7 (CK-7), while round cells were positive with TTF-1 and EMA. Until the end of last contact, none of the patients died or suffered from the recurrence of the disease after surgical treatment.ConclusionsPulmonary SH is a unique neoplasm of the lung with a characteristic solitary mass or nodule. Pulmonary epithelium might be the primary origin of the tumor cells.
Highlights
Pulmonary sclerosing hemangioma (SH) is an uncommon tumor
Pulmonary sclerosing hemangioma (SH) is a rare neoplasm, which was described by Liebow and Hubbell over 50 years ago [1]
Notwithstanding the original term of ‘sclerosing hemangioma’, more and more evidence suggested it might not be derived from vascularendothelium [4,5,6]
Summary
Pulmonary sclerosing hemangioma (SH) is an uncommon tumor. The aim of this study was to identify the origin of pulmonary SH and summarize its clinicopathologic features. Pulmonary sclerosing hemangioma (SH) is a rare neoplasm, which was described by Liebow and Hubbell over 50 years ago [1]. Though it was generally regarded as a benign tumor, its histogenesis and biologic behaviors is still a controversy [2,3,4,5,6,7]. We reviewed 26 cases of pulmonary SH patients, including their clinical manifestations, radiological findings, treatments, and pathological results, to explore and summarize its characteristics
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