Abstract
SettingOur study was conducted at a tertiary care center for respiratory illnesses (Viswanathan Chest Hospital, Vallabhbhai Patel Chest Institute (VPCI), University of Delhi, Delhi, India). Patients were enrolled in the study from the outpatient clinic.ObjectiveTo assess the effects of pulmonary rehabilitation (PR) in patients with chronic lung impairment from previously treated tuberculosis (CLIPTB), on exercise capacity (six-minute walk distance), pulmonary function tests, quality of life and markers of systemic inflammation.DesignProspective cohort study including 29 patients who had finished anti-tubercular therapy and currently had symptoms of dyspnea with or without cough secondary to CLIPTB.ResultSignificant improvement in six-minute walk distance (488 meters at baseline vs 526 meters post PR intervention, p-value 0.033) and chronic respiratory questionnaire score (17.21 at baseline vs 18.96 post PR intervention, p-value 0.025) with pulmonary rehabilitation was noted. Pulmonary function tests, inflammatory markers and mid-thigh muscle mass trended towards improvement with pulmonary rehabilitation but were not statistically significant.ConclusionOur study shows that pulmonary rehabilitation is an effective intervention in post-tuberculosis patients and should be recommended.
Highlights
Tuberculosis (TB) is the ninth leading cause of death worldwide and the leading cause from a single infectious agent, ranking above human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)
Our study shows that pulmonary rehabilitation is an effective intervention in post-tuberculosis patients and should be recommended
An estimated 10.4 million people fell ill with TB in 2016 — 90% were adults, 65% were male, 10% were people living with HIV (74% in Africa) and 56% were from five countries: India, Indonesia, China, Philippines and Pakistan [1]
Summary
Tuberculosis (TB) is the ninth leading cause of death worldwide and the leading cause from a single infectious agent, ranking above human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). In 2016, there were an estimated 1.3 million TB deaths among HIV-negative and an additional 374,000 deaths among HIV-positive people. An estimated 10.4 million people fell ill with TB in 2016 — 90% were adults, 65% were male, 10% were people living with HIV (74% in Africa) and 56% were from five countries: India, Indonesia, China, Philippines and Pakistan [1]. India accounts for ~27% of the global TB incident cases. Each year an estimated 2.7 million people in India develop TB, the incident-reported cases were about ~1.9 million in 2016. 84% of reported cases are of pulmonary origin. It is estimated that around 435,000 Indians died due to TB in 2016 [2]
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