Abstract
Background: The present study was performed to investigate the protective effects of propofol against cisplatin-induced pulmonary toxicity in rats. Methods: A total of 20 male Wistar rats weighing 180-250 g were divided into four groups of control, the cisplatin-intoxicated group intraperitoneally (IP) injected with cisplatin (7 mg/kg/d for a week), the propofol group (10 mg/kg/d, IP), and the protected group receiving propofol (10 mg/kg/d, IP) poisoned by cisplatin. Then, the biomarkers of total antioxidant capacity (TAC), catalase (CAT) activity, and lipid peroxidation (LPO) were measured in homogeneous lung tissues. Results: The data revealed the evidence of oxidative stress in the lung tissue of cisplatin-intoxicated rats as indicated by an increase in the level of LPO compared with propofol and protected groups (P<0.05). Moreover, TAC decreased in the cisplatin group while it increased in the propofol group compared to cisplatin and protected groups (P<0.05). No significant difference was observed between the groups regarding CAT (P>0.05). Protection with propofol ameliorated the oxidative stress induced by cisplatin in the lung tissue because of the reduction of LPO. Conclusion: According to these results, it seems that propofol provides a remarkable protection against cisplatin-induced oxidative pulmonary damage mediated by its antioxidant properties.
Highlights
Cisplatin (diamminedichloroplatinum (II)) is strongly believed to be one of the most important cytotoxic anticancer medications due to its broader efficacy in treating various types of cancer such as brain, neck, ovarian, lung, testicular, cervical, and breast [1]
The present study investigated the antioxidant characteristics of propofol against cisplatin-induced pulmonary toxicity in rats
Oxidative Stress Parameters Lipid Peroxidation Based on the results (Figure 1), cisplatin caused a noticeable increase in lipid peroxidation (LPO) compared with the control group (P = 0.011) while propofol induced a significant decrease in LPO in comparison with the cisplatin group (P = 0.007)
Summary
Cisplatin (diamminedichloroplatinum (II)) is strongly believed to be one of the most important cytotoxic anticancer medications due to its broader efficacy in treating various types of cancer such as brain, neck, ovarian, lung, testicular, cervical, and breast [1]. The primary cytotoxic mechanism is the formation of a DNA adduct [2] Along this line, cisplatin treatment has been linked to various toxic side effects including hepatotoxicity, nephrotoxicity, cardiotoxicity, neurotoxicity, and nausea [3]. Cisplatin treatment has been linked to various toxic side effects including hepatotoxicity, nephrotoxicity, cardiotoxicity, neurotoxicity, and nausea [3] These adverse effects of cisplatin-induced pulmonary damage have been attributed to increased lipid peroxidation (LPO) caused by free oxygen radicals and decreased antioxidant parameters [4]. Results: The data revealed the evidence of oxidative stress in the lung tissue of cisplatin-intoxicated rats as indicated by an increase in the level of LPO compared with propofol and protected groups (P
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
