Abstract
Pulmonary papillary adenoma is a very rare tumor usually presenting in periphery of the lung. Herein, we present a case of pulmonary papillary adenoma located in central portion of the lung in a 17 year-old Chinese female. A well-defined mass was incidentally detected at right pulmonary hilar region by imaging examination. Histologically, the tumor is predominantly composed of abundant papillary structures lined by columnar to cuboidal epithelial cells resembling type II pneumocytes. Immunohistochemical staining showed that the epithelial cells were diffusely positive for cytokeratin, cytokeratin7, TTF-1, EMA, surfactant apoprotein A, Napsin A, P63 and β-catenin. The Ki-67 proliferation index was approximately 2 %. Based on morphologic features and the immunohistochemical profile, the tumor was consistent with pulmonary papillary adenoma. Thus, it should be noted that pulmonary papillary adenoma was also a possible diagnosis for a central mass.
Highlights
Pulmonary papillary adenoma is a very rare tumor that first described by Fantone et al in 1982 [1]
We present a case of pulmonary papillary adenoma located in the central portion of the lung in a 17 year-old Chinese female
Tissue blocks were cut into 4-μm slides, deparaffinized in xylene, rehydrated with graded alcohols, and immunostained with the following antibodies: cytokeratin (CK), cytokeratin7(CK7), CD68, Vimentin, thyroid transcription factor 1 (TTF-1), epithelial membrane antigen (EMA), surfactant apoprotein A (SPA), Napsin A, synaptohysin, CD56, P63 and β-catenin, p53 and Ki-67
Summary
Pulmonary papillary adenoma is a very rare tumor that first described by Fantone et al in 1982 [1]. Less than 25 cases were reported in the English literature [2,3,4,5,6,7,8,9,10,11,12,13,14,15,16]. We present a case of pulmonary papillary adenoma located in the central portion of the lung in a 17 year-old Chinese female. This tumor was generally considered benign; some scientists thought that it might have malignant potential because of its microinvasive characteristics [9, 10]. The patient was alive with no evidence of tumor recurrence or metastasis within 12 months of follow-up
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