Abstract
Prolonged continuous exposure of adult (3–4 months) and old (21 months) mice to hyperoxia did not lead to significant changes in the activities of superoxide dismutase and catalase in liver or blood. Lung superoxide dismutase activity increased by 25% during initial exposure to 100% O 2, but then fell progressively to below control level. Exposure of mice to 60% or 80% O 2 increased their susceptibility to further exposure to 100% O 2. The results clearly show that both adult and old mice are incapable of coping with the high oxygen environment and that antioxidant enzyme induction and the associated partial protection from pulmonary O 2 toxicity are not the general rule in mammalian lung exposed to subtoxic oxygen levels.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
