Pulmonary Hypertension in Patients Starting Peritoneal Dialysis

Abstract

Cardiovascular complications are the major cause of morbidity and mortality in patients with chronic kidney disease (CKD). One such complication is pulmonary hypertension (PH). Its prevalence in patients in peritoneal dialysis (PD) varies from 12.6-41.7% and its related factors are not well known. The main objective of this multicenter study was to determine the prevalence of PH and its risk factors in patients starting in PD. Patients incident in PD were studied. Clinical, biochemical, and PD parameters were evaluated. A transthoracic echocardiography was performed and the evaluated according to the American Society of Echocardiography. Systolic pulmonary artery pressure (sPAP) was calculated with tricuspid regurgitation gradient and PH considered if pulmonary artery pressure was ≥35mmHg. There were 105 men and 72 women included in the study (aged 53.7±12.8 vs. 52.9±15.5years). PH was found in 69 patients (38.98%), they had sPAP of 49.05±13.80 vs. 18.81±11.15 mmg, in patients without PH (p <0.001). Patients with PH tend to be more frequently men than women (42 vs. 35%, p=0.33), and were younger (51.0±14.9 vs. 55,1±12.8years; p=0.05). Risk factor for PH were diastolic dysfunction of the left ventricle (LV) (OR=1.46, 95% CI 1.094-1.973), left ventricular hypertrophy (LVF) (OR=2.56, 95% CI 1.29-5.09); and residual renal function (RRF) was a protector factor (OR=0.78, 95% CI 0.068-0.915). Prevalence of PH in patient's incident in PD was 38%. The factors associated with PH were diastolic dysfunction of the LV and LV hypertrophy. RRF was a protector factor.