Abstract

Pulmonary function of 10 patients who had serologically confirmed, uncomplicated A2 influenza was studied during the acute illness and at two- and six-week follow-up periods. Six patients had significant but reversible decreases in pulmonary function manifested by restrictive ventilatory defects and increased alveolar-arterial oxygen tension gradients. Evidence of airway obstruction was found in only one patient. Administration of a bronchodilator aerosol produced no significant change in ventilatory function or arterial blood gas measurements. These data indicate that apparently uncomplicated influenza is frequently accompanied by abnormalities in pulmonary function that are probably related to viral invasion of the lower respiratory tract despite normal chest radiographs.

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