Abstract

Abstract Introduction: The influenza A (H1N1) was responsible for the 2009 pandemic, especially with severe pulmonary complications. Objective: To describe characteristics of patients in a university hospital in Curitiba - PR with laboratory diagnosis of influenza A (H1N1) and its post hospital discharge in the 2009 lung function pandemic. Methodology: A retrospective observational study. It was used as a data source the institution Epidemiology Service (SEPIH) and spirometry tests of patients who were admitted in 2009, 18 years without lung disease associated and non-pregnant. Descriptive statistics were used and applied Fisher's exact test for relationship between comorbidity and spirometry tests. Results: There were 84 confirmed cases, of these 11 were eligible for the study with a mean age of 44.27 years (± 9.63) and 63.63% males. 54.54% of the 11 patients had comorbidities associated with systemic arterial hypertension (54.54%), diabetes (18.18%) and late postoperative period of kidney transplantation (18.18%) were the most frequent. Most patients (81.81%) had BMI ≥ 25kg / m². The Spirometry test was performed approximately 40.09 (± 15.27) days after discharge, of these, 5 had restrictive pattern and all had abnormal chest radiograph results. There was no statistically significant difference between the results of Spirometry and comorbidities (p=0.24). Conclusions: The group evaluated in this research did not show a direct relationship between Spirometry and comorbidities, but changes in Spirometry in some patients after hospital discharge stood out, suggesting changes in lung function due to influenza A (H1N1).

Highlights

  • In the end of the 80's there was an outbreak of infection by the In luenza A virus (H1N1) in a region of the United States of America (USA) especially attacking young people with a signi icant morbidity (1), bringing about a subsequent mass vaccination

  • The patients included in the study were hospitalized in the HC – UFPR hospital during the referred period with a laboratory diagnosis of in luenza A (H1N1), who did not die during hospitalization, with age above 18 years, without associated lung disease, non-pregnant and who underwent the Spirometry exam in 2009

  • The body mass index (BMI) was classi ied separately, according to the World Health Organization (15), the patients were classi ied as ideal weight (18.18%), overweight (36.36%), grade I obesity (9.09%), grade II obesity (27.27%) and morbid obesity (9.09%)

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Summary

Introduction

In the end of the 80's there was an outbreak of infection by the In luenza A virus (H1N1) in a region of the United States of America (USA) especially attacking young people with a signi icant morbidity (1), bringing about a subsequent mass vaccination. The irst cases were detected precisely on April 11th 2009 in the city of Veracruz in Mexico, and it went on to becoming a level 6 pandemic in the beginning of June of the same year, de ining the gravity of the pathology caused by the virus and its geographical extension (2, 3). According to the World Health Organization (WHO) (3), from April to December 2009, 208 countries were noti ied, in total 12,799 deaths from In luenza A (H1N1) con irmed by laboratory exams. Brazil registered a total of 2,051 deaths. The southern region presented a higher rate of mortality, being 3/100 thousand inhabitants (840 deaths) (4, 3)

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