Abstract
The effects of cold acclimatization on pulmonary function during norepinephrine-induced calorigenesis were studied. Norepinephrine resulted in a marked increase (85%) in the pulmonary minute volume in both the warm- and cold-acclimatized rats. This increase in the warm-acclimatized rats was accomplished entirely by increasing the respiratory rate, whereas in the cold-acclimatized rats, the increase in pulmonary minute volume was achieved for the most part by increasing the tidal volume with a slight increase in respiratory rate. Cold acclimatization was associated with a greater “efficiency of oxygen extraction” before, during, and after the infusion of norepinephrine. pulmonary minute volume; respiratory rate; oxygen extraction Submitted on December 6, 1962
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