Abstract
The grade of malignancy of rare, vascular pulmonary epithelioid hemangioendothelioma (PEH) is low to intermediate. These tumors can simultaneously or sequentially arise from the lungs, liver, bone and soft tissue, which renders multicentric tumor growth difficult to distinguish from primary lesions with metastasis to other tissues. Most patients with pulmonary epithelioid hemangioendothelioma (PEH) are female (61–80%) and the median age is 36–50 years, which is relatively younger than those with lung cancer. No specific symptoms are associated with PEH, and 50–76% of patients are asymptomatic at the time the condition is detected by chest radiography. Our patient was also asymptomatic. Multiple pulmonary nodules, multiple pulmonary reticulonodular opacities, and diffuse infiltrative pleural thickening have been identified by computed tomography (CT) scan. The most common feature of PEH on chest CT scan is the presence of multiple small discrete pulmonary nodules of up to 2 cm with well-defined margins in both lungs. However, most nodules are less than 1 cm in diameter.
Highlights
Computed tomography (CT) scan showed bilateral, nodular, lung shadows in an asymptomatic 38yearold female (Figure 1)
No specific symptoms are associated with pulmonary epithelioid hemangioendothelioma (PEH), and 50–76% of patients are asymptomatic at the time the condition is detected by chest radiography
Multiple pulmonary reticulonodular opacities, and diffuse infiltrative pleural thickening have been identified by computed tomography (CT) scan [1]
Summary
Computed tomography (CT) scan showed bilateral, nodular, lung shadows in an asymptomatic 38yearold female (Figure 1). Five nodules up to 10 mm each were identified in the right and left lungs. She was followed up for four months, during which the size and density of these shadows remained unaltered. The patient requested a definitive diagnosis and underwent a video assisted thoracoscopic lung biopsy of two lesions in the right lower lobe (S6c, S9a). These findings supported a diagnosis of pulmonary epithelioid hemangioendothelioma (PEH) (Figure 2). All other organs were free of abnormalities and the patient was remained under observation for two years without treatment or disease progression
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