Abstract
Although F hyperinsulinemia is thought to be related to reduced surfactant synthesis, the mechanisms for the ↑ incidence of RDS in the IDM remain unclear. Role of EGF in F lung (L) maturation is well established. Development of L EGF R in the F of alloxan induced (110 mg/kg I.V. at 14d) D rabbit doe was studied at 27 and 30d. Microscopic examination of F pancreas revealed hypertrophy of beta cells. Lung plasma membranes (LPM) were isolated and characterized by mg of protein, % recovery, DNA and 5'-nucleotidase. No. of R sites were calculated by 125I-EGF binding assays. Scatchard plots were linear. (All data x̄ ± SEM, *P<.02 compared to age controls)Conclusion: Alloxan induced M.D. does not influence the development of F pulmonary EGF R.
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