Pulmonary effects of carmustine (bischloroethylnitrosourea, BCNU)

Abstract

Letters and Corrections1 July 1979Pulmonary Effects of Carmustine (Bischloroethylnitrosourea, BCNU)ROBIN L. KAPLAN, M.D.ROBIN L. KAPLAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-1-131_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report by Durant and colleagues in the February issue (1) is interesting, but, with one exception, their patients are not convincing examples of persons who have developed pulmonary toxicity secondary to carmustine (bischloroethylnitrosourea, BCNU). Nine of the 10 patients were receiving one or more drugs known to produce hypersensitivity reactions or fibrosis simultaneously with carmustine. Only the patient with glioblastoma received no prior or concurrent chemotherapy. In addition, five of the 10 patients (including the patient with glioblastoma) had received prior radiation therapy. However scrupulously the lungs had been shielded, it is difficult to completely exclude...Reference1. DURANTNORGARDMURADBARTOLUCCILANGFORD JMTAK. Pulmonary toxicity associated with bischloroethylnitrosourea (BCNU). Ann Intern Med. 1979;90:191-4. LinkGoogle Scholar1. HOLOYEJENKINSGREENBERG PDS. Pulmonary toxicity in long-term administration of BCNU. Cancer Treat Rep. 1976;60:1691-4. MedlineGoogle Scholar2. WEISSSHAHSHANE RSS. Pulmonary toxicity from carmustine (BCNU). Med Pediatr Oncol. 1979;6. In press. CrossrefMedlineGoogle Scholar3. DURANTNORGARDMURADBARTOLUCCILANGFORD JMTAK. Pulmonary toxicity associated with bischloroethylnitrosourea (BCNU). Ann Intern Med. 1979;90:191-4. LinkGoogle Scholar4. PATELSHAHRHEESASSOONROO APHHK. Cyclophosphamide therapy and interstitial pulmonary fibrosis. Cancer. 1976;38:1542-9. CrossrefMedlineGoogle Scholar5. LEEMOOREWAMPLER WRG. Interstitial pulmonary fibrosis as a complication of prolonged methyl-CCNU therapy. Cancer Treat Rep. 1978;62:1355-8. MedlineGoogle Scholar1. DURANTNORGARDMURADBARTOLUCCILANGFORD JMTAK. Pulmonary toxicity associated with bischloroethylnitrosourea (BCNU). Ann Intern Med. 1979;90:191-4. LinkGoogle Scholar2. GREEN M. Pulmonary toxicity of antineoplastic agents. West J Med. 1977;127:292-8. MedlineGoogle Scholar3. LIPPMANN M. Pulmonary reaction to drugs. Med Clin North Am. 1977;61:1353-67. CrossrefMedlineGoogle Scholar4. SOSTMANMATTHAYPUTNAM HRC. Cytotoxic drug-induced lung disease. Am J Med. 1977;62:608-15. CrossrefMedlineGoogle Scholar5. CROOKEBRADNER SW. Bleomycin, a review. J Med. 1976;7:333-428. MedlineGoogle Scholar1. DURANTNORGARDMURADBARTOLUCCILANGFORD JMTAK. Pulmonary toxicity associated with bischloroethylnitrosourea (BCNU). Ann Intern Med. 1979;90:191-4. LinkGoogle Scholar1. SELKERJACOBSMOORE RSP. Interstitial pulmonary fibrosis as a complication of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy. Proc Am Assoc Cancer Res. 1978;19:333. Abstract. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Colorado Medical Center Denver, CO 80262 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIatrogenia a fármacos no contexto do Aparelho RespiratórioCYCLOPHOSPHAMIDE: PULMONARY METABOLISM, TOXICITY AND PROTECTIVE EFFECT OF VITAMIN EPulmonary Effects of Cytotoxic Agents Other Than BleomycinMetabolism and pulmonary toxicity of cyclophosphamideDrug-induced pulmonary diseasePulmonary toxicity of antitumor agentsThe nitrosoureas and pulmonary toxicityCytotoxic drug-induced pulmonary disease: Update 1980 1 July 1979Volume 91, Issue 1Page: 131-133KeywordsChemotherapyDrugsFibrosisGlioblastoma multiformeHypersensitivityLungsRadiation therapyToxicity Issue Published: 1 July 1979 PDF downloadLoading ...