Abstract
Regression equations for pulmonary diffusing capacity (D LCO) were computed from data obtained on sixty-nine normal boys and fifty-seven normal girls, between the ages of 6 and 15. Similarly, equations were computed for pulmonary membrane diffusing capacity (D MCO) and capillary blood volume (Vc) from data obtained on forty-five normal boys and thirty-one normal girls. Ten children with intractable asthma with chronic overinflation had an increased pulmonary diffusing capacity and a markedly increased membrane diffusing capacity. These changes from the normal are statistically significant. The capillary blood volume is less than predicted but the difference is not statistically significant. Increased pulmonary diffusing capacity is a summation of a moderate increase in pulmonary surface area due to overinflation and a greater decrease in membrane thickness. Six children with intermittent overinflation had higher than predicted values for diffusing capacity and membrane diffusing capacity which were not significantly different, while the values for capillary blood volume were the same as the predicted. Ten children without overinflation had values the same as the predicted for diffusing capacity, membrane diffusing capacity, and capillary blood volume. Overinflation with increased surface area and thinner membranes does not appear to be affected by treatment with steroid drugs.
Published Version
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