Abstract
Animals were subjected to pulmonary contusion and hemorrhage (30 mlg/kg), and blood volume was restored with plasma equal to and three times the blood volume and Ringer's lactate solution in a volume three times the shed blood. Varying rates of infusion of RLS were used. Colloid replacement caused only a moderate increase in lung weight on the contused side with maintenance of a normal pO2 and plasma protein level. Ringer's replacement at 30 ml/kg/hr caused few changes in pO2, plasma protein, or lung weight, while increasing the rate of RLS infusion caused deterioration of oxygenation with low levels of plasma protein. There was marked histologic worsening of the lung contusion with an increase in lung weight and water content. Plasma replacement was superior to RLS for volume replacement after pulmonary contusion, with the rate of RLS infusion being a critical factor in the development of pulmonary insufficiency.
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