Abstract
Pulmonary benign metastasizing leiomyoma characterized by the growth of uterine leiomyoma in the lung is a very rare disease. We herein report the case of a 46-year-old asymptomatic woman who underwent a total abdominal hysterectomy for her multiple uterine leiomyomas 5 years ago, with the presence of multiple shadows in her chest roentgenogram during the regular check-up. Chest computerized tomography (CT) showed multiple solitary nodules in both lungs. Video-assisted thoracoscopic surgery with a wedge resection of the lesion was performed. Histopathologically, the pulmonary nodule was composed of benign smooth muscle cells and demonstrated low mitotic activity and absence of necrosis. Immunohistochemical staining for smooth muscle actin (SMA) and Desmin were extremely positive. CD10, CD117 and S-100 were negative in the tumor cells. Positive immunoreactivity for estrogen receptor (ER) and progesterone receptor (PR) were detected. The pathological diagnosis was pulmonary benign metastasizing leiomyoma.
Highlights
Pulmonary benign metastasizing leiomyoma is a very rare disease characterized by the growth of uterine leiomyoma tissue in the lung [1]
There is a previous history of total abdominal hysterectomy for uterine leiomyoma
Abramson et al reported that the average age of patients with benign metastasizing leiomyoma is 48 years old, with the period from hysterectomy to nodule detection varying from 3 months to 26 years [2]
Summary
Pulmonary benign metastasizing leiomyoma is a very rare disease characterized by the growth of uterine leiomyoma tissue in the lung [1]. The patient’s past medical history showed a diagnosis of multiple uterine leiomyoma in 2005 for which a total abdominal hysterectomy had been performed. Postoperative pathological examination showed a pulmonary benign metastasizing leiomyoma, consisting of revealed spindle-shaped cells with abundant clear cytoplasm and distinct cell borders. It demonstrated low mitotic activity (
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