Abstract
Effects of PGI 2 upon pulmonary vascular resistance and systemic arterial pressure of near term features were evaluated in anesthetized, exteriorized, unventilated fetal lambs by means of an open-chest, pump-perfused lung preparation. These effects were compared to those of PGE 1 and PGE 2 in the same animals. Intrapulmonary arterial infusions of PGI 2 produced dose-dependent decreases in pulmonary vascular resistance and systemic arterial pressure. Effects of PGI 2 upon pulmonary vascular resistance are intermediate with respect to those of PGE 1 (greater) and PGE 2 (less). PGI 2 is a potent hypotensive compound when administered to fetal lambs, producing dose-dependent decreases in systemic arterial pressure. When the three prostaglandin are infused into the pulmonary artery, effects on systemic arterial pressure of PGE 1 and PGI 2 are nearly identical. Effects of PGE 2 are considerably less. PGI 2 is a potent dilator of fetal lamb vessels and could play a role in circulatory control during perinatal transition.
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