Abstract
AbstractSix ophthalmic beta-blockers-betaxolol, timolol, levobunolol, pindolol, befunolol, and metipranolol-and placebo eyedrops were tested in six normal volunteers for their effect on exercise heart rate, blood pressure, and electrocardiogram tracings. None of the solutions affected blood pressure or electrocardiogram results. Betaxolol and placebo did not affect heart rate. However, all the other agents significantly (p < 0.05) suppressed the heart's ability to respond to exercise.These same formulations were tested by spirometry in six asdimatic patients. Betaxolol and placebo had no effect on forced expiratory volume at 1 sec (FEV,), whereas all the other agents significantly (p < 0.05) depressed vital lung function.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Toxicology: Cutaneous and Ocular Toxicology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
