Pulmonary air trapping during two-lung and one-lung ventilation

Abstract

Objective: Evaluation of the magnitude of pulmonary air trapping during routine thoracic surgery and single-lung transplantation. Design: Prospective study on consecutive patients. Setting: Single institution, university hospital. Participants: Sixteen patients with no or moderate obstructive lung disease undergoing routine thoracic surgery (group 1), six patients with severe emphysema (group 2), and six patients with severe fibrosis (group 3) undergoing single-lung transplantation. Interventions: Occlusion maneuver timed at the end of expiration to measure auto-positive end-expiratory pressure (auto-PEEP) and trapped volume ( Δ FRC). The maneuver was performed during two-lung ventilation in supine (2LV supine) and lateral decubitus (2LV lateral) positions and during one-lung ventilation (OLV) in lateral decubitus position. At the same time, airway pressures and PaO 2 measurements were performed. Measurements and Main Results: In group 1, consistent values of auto-PEEP and Δ FRC occurred only during OLV: 4.8 ± 2.5 cm H 2O and 109 ± 61 mL (mean ± standard deviation). In group 2, auto-PEEP and Δ FRC values were 11.7 ± 6.9 cm H 2O and 355 ± 125 mL during 2LV supine, 8.8 ± 5.7 cm H 2O and 320 ± 122 mL during 2LV lateral, and 15.9 ± 3.9 cm H 2O and 284 ± 45 mL during OLV. In group 3, pulmonary air trapping was low. For the three groups together, auto-PEEP and Δ FRC ( p < 0.0001) related inversely to the ratio of forced expired volume in 1 second (FEV 1) to forced vital capacity (FVC) expressed in percent (FEV 1/FVC%) during OLV. In contrast, there was no correlation between PaO 2 and auto-PEEP or Δ FRC. Conclusion: Pulmonary air trapping must be suspected in patients with no or moderate obstructive lung disease during OLV and in those with severe obstructive disease as soon as 2LV is initiated.