Pulmonalis adenocarcinomaval társult dermatomyositis adalimumab terápiában részesülő beteg esetében – esetbemutatás

Abstract

A 63-year-old woman is presented who was hospitalized with generalized skin lesions and progressive proximal muscle weakness. In her medical history there was a long term adalimumab treatment of psoriatic arthritis. Laboratory results presented high creatin kinase, lactate dehydrogenase and liver enzymes. Chest-, abdomen and pelvis CT scan showed a mass in the right lung and in the mediastinum. Histology verified adenocarcinoma of the lung. As clinical findings, laboratory results and medical imaging results confirmed tumor associated dermatomyositis, parenteral steroid and methotrexate medication was initiated. Further examniation and treatment were performed on pulmonology department. In the cases of dermatomyositis tumor search is crucial. Chronic inflammation is related to carcinogenesis. The relationship between tumor necrosis factor alpha inhibitor treatment and cancer risk is not clear, however patients with active or prior cancer, or those with high risk for developing cancer should be treated with special attention.