Abstract
A paper in this issue discloses the secret of eternal youthat least for neural progenitors. During neurogenesis, self-renewing progenitor cells that reside in the ventricular zone of the developing CNS exit the cell cycle, migrate toward the marginal zone, and differentiate into neurons. Previous studies have identified transcription factors that promote the formation of new neurons by directing stem cells to stop dividing. However, the mechanisms responsible for countering differentiation to maintain a pool of undifferentiated neural progenitor cells have been less clear.
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