Abstract
For directed cell movement, cells need to extend their plasma membrane towards sources of chemoattractant. Actin polymerization is known to play a critical role in this process, and we know many of the actin regulators that link attractant receptors with the actin cytoskeleton. Much less studied are the complementary regulators of membrane extension such as water influx, which is thought to collaborate with actin polymerization to inflate the leading edge for cell protrusion. We study this question in human neutrophils, cells of the innate immune system that migrate to sites of injury and infection to hunt and kill invading pathogens.
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