Abstract
This study aimed to determine the relationship between clinicopathologic features and lung squamous cell carcinoma subtypes according to the 2015 WHO classification. We identified 368 operable lung squamous cell carcinoma patients who had undergone a complete surgical resection at Shanghai Chest Hospital between April 2015 and March 2016. Among all patients, the percentages of lung squamous cell carcinoma subtypes were: 68.5% (252/368), 26.2% (97/368), and 5.1% (19/368) for keratinizing squamous cell carcinoma (KSCC), nonkeratinizing squamous cell carcinoma (NKSCC), and basaloid squamous cell carcinoma (BSCC), respectively. There were more smokers in patients with KSCC than in patients with other subtypes (p=0.004). There were no significant relationships between pathological subtypes and other clinicopathologic features, such as gender, age, location type, type of resection, stage, visceral pleural involvement, lymphovascular invasion, and lymph node involvement. The expressions of P40, CK5/6, TTF-1, Napsin A, and CK7 were also not significantly different in three subtypes. Our study revealed that there were no significant relationships between clinicopathologic features and lung squamous cell carcinoma subtypes.
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