PUB058 Pulmonary Intestinal-Type Adenocarcinoma

Abstract

Intestinal-type adenocarcinoma is a rare pulmonary cancer. Cystic change as image feature in lung cancer patients is also quite uncommon. Here we report a rare case of pulmonary intestinal-type adenocarcinoma with multiple cystic changes in CT image. Fig 2Immunohistochemical staining for cytokeratin 7(CK7) and CK20 were positive.View Large Image Figure ViewerDownload Hi-res image Download (PPT) The patient was a 67-year-old woman. A computed tomographic scan of the chest revealed multiple cystic changes in the both sides of her lung (Fig 1). Tumor markers such as CEA, cyfra211 and SCC were mild elevated. Sputum cytology and transbronchial examination didn’t find cancer. PET-CT revealed high FDG accumulation at the lesion in the lung. She did the CT guided lung biopsy . Histopathologically, the tomor consisted predominantly of colorectal carcinoma-like components, composed mainly of tall columnar cells with a brush-border and eosinophilic cytoplasm. Immunohistochemical staining for CK7 and CK20 were positive (Fig 2), whereas TTF-1 and napsin-A were negative. The final diagnosis was primary pulmonary intestinal-type adenocarcinoma. There are few reported cases of pulmonary intestinal-type adenocarcinoma. More experience of such cases is needed to further understand this rare variant of adenocarcinoma.