Abstract
PU.1 is a tumor suppressor for B cell malignancies
Highlights
PU.1 is a critical transcription factor for differentiation of both myeloid and lymphoid cells
In late B cell development, the loss of PU.1 expression induced by a CD19-Cre system had no effect on B cell differentiation [5], suggesting that PU.1 may not be necessary for mature B cell differentiation
We demonstrated that a lentiviral system containing PU.1 could induce apoptosis in primary Hodgkin lymphoma purified from patients
Summary
PU.1 is a critical transcription factor for differentiation of both myeloid and lymphoid cells. These observations prompted us to try to elucidate the function of PU.1 in B cell malignancies, starting with multiple myeloma, a malignancy of plasma cells. We have demonstrated that downregulation of PU.1 in myeloma cell lines is caused by an epigenetic mechanism. Conditional expression of PU.1 using a Tet-off system induced growth arrest and apoptosis in myeloma cell lines [6].
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