PTU-186 Exogenous NSAID exposure increases transcriptional expression of the 5-lipoxygenase pathway in normal squamous tissue, but not in Barrett's metaplasia: an ex vivo study of oesophageal biopsy specimens

Abstract

IntroductionBarrett's oesophagus (BO) is a premalignant condition for oesophageal adenocarcinoma, an increasingly common malignancy with poor survival. The prostanoids and leukotrienes are lipid inflammatory mediators derived from a common precursor...