Abstract
A simple, efficient, cost-effective and one-pot eco-friendly protocol has been developed for the synthesis of new isoxazolyl-4-hydroxyindole-3-carboxylate derivatives by using 4-amino-3-methyl-5-styrylisoxazoles, 2,3-diketoesters and 1,3-cyclohexanediones, in the presence of p-toluenesulfonic acid (p-TSA) catalyst in aqueous medium. The advantages of this protocol are inexpensive catalyst, metal-free, shorter reaction time, environmentally friendly, high yields, water as a solvent, wide substrates scope and easy purification.
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