PTP1B and α-glucosidase inhibitory activities of Hedera rhombea compounds

Abstract

To obtain antidiabetic active compounds from the natural sources, we led to the isolation of 32 compounds from the fruits of Hedera rhombes. Their structures and absolute configurations were elucidated by extensive analysis of NMR spectroscopic data, HRMS, and ECD calculations [1]. Among the isolated compounds ([Fig. 1]), falcarindiol and caffeoyltryptophan showed significant PTP1B inhibition with IC50 values of 7.32 and 16.99 µM, respectively, compared to those of the positive controls [sodium orthovanadate (IC50 = 17.96 µM) and ursolic acid (IC50 = 4.53 µM)]. These two compounds along with several other compounds displayed significant α-glucosidase inhibitions with IC50 values ranging from 12.88 to 91.89 µM, stronger than that of the positive control (acarbose, IC50 = 298.07 µM) [2].