Abstract
Post translational modifications like phosphorylation, Glycosylation and ADP ribosylation serves as biomarkers and are mainly involved in regulation of signalling pathways, cell polarity and cell cycle progression. So, this review helps in finding the biomarkers in understanding of cancer genome and also the deviations observed in gating mechanisms. Mucin 3 is mainly involved in EMT transition and Phosphorylation is also required for effective complex formation between catenin and cadherin. Hyaluron acts as medium for the tumors cells and aids in their movement and responsible for metastatic development. Epigenetic modification like methylation is helpful for cancerous genome to develop additional mutations for survival of the genome.
 Key words: Cyclin D, PTMs, Gating, Glycosylation, Phosphorylation.
Highlights
Post translational Modifications are generally necessary for the functionality of proteins and in the direction to its location for example attachment to plasma membrane but some of the post translational modifications (PTM) acts as biomarkers and is necessary for survival of certain cancers like breast cancer
Considering the our constrain we focus on post translational modifications and genes that cause cell cycle arrest in normal and cancerous tissues and understanding the mechanism at both gene level and at the molecular level
Phosphorylation and glycosylation and unoftenly ADP ribosylation can leads to more disastrous disorder
Summary
Eswari beeram Assistant Professor, Sree Vidyanikethan Degree College, A.P, India Article Info: Received 20 April 2019; Accepted 14 May. 2019 DOI: https://doi.org/10.32553/ijmbs.v3i5.245 Corresponding Author: Eswari beeram, Assistant Professor, Sree Vidyanikethan Degree College, A.P, India Conflict of interest: No conflict of interest.
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