PTH-063 Nutritional requirements and prevalence of cholestasis in patients with a short bowel due to infarction

Abstract

Introduction Patients with a short bowel and a retained colon due to ischaemia are now the most common indication for home parenteral nutrition in the UK.1 To date most studies have compared short bowel length and intravenous nutrition (IVN) requirements in patients with mixed aetiology of intestinal failure.2 IVN patients with Methods Retrospective data were collected using St Mark9s Intestinal Failure database. Biochemical parameters obtained from computer lab system. Chronic cholestasis was considered to be two of bilirubin, alkaline phosphatise or γ-glutamyl transferase >1.5 times the upper limit of normal for >6 months.3 Results Since 2003 a total of 88 patients (male 47%) have been referred to St Marks Intestinal Failure Unit with SB infarction. 12-month follow-up data were available for 57 patients diagnosed with arterial SB infarction (46% male, mean age at diagnosis 56.3 years) and four patients with venous SB infarction (male 25%, mean age at diagnosis 35.5 years). Following continuity surgery 92% of patients with SB length 12 months after initial diagnosis. In comparison only 28% with SB length >50 cm were receiving IVN. Comparing patients that were receiving and not receiving IVN there was a significant difference in residual SB length (p= 50 cm. Following continuity surgery 31% with residual SB 50 cm. All five patients (4 patients 12 months following diagnosis had chronic cholestasis. Conclusion Residual SB length corresponds to IVN requirements. Less than