Pterostilbene, a natural analogue of resveratrol, decreases hepatic lipid deposition by increasing triacylglycerol hydrolases activity (1116.6)

Abstract

In the present work the role of pterostilbene on lipid metabolism was evaluated in a rodent obesity model induced by monosodium glutamate (MSG) during the first ten days of life. At 70 days of age, control (C) and MSG (M) animals were divided into groups that received by gavage pterostilbene (P) (40 mg.kg‐1.day‐1) or vehicle (V) during 20 days. After removal of liver and adipose tissue, triacylglycerol (TAG) hydrolases activity was evaluated and SIRT‐1 (sirtuin‐1) expression was determined by real time PCR. The results obtained in fed rats showed increase in Lee index and visceral adiposity in MSG group (MV) in relation to control (CV). Treatment of obese rats with pterostilbene (MP) decreased Lee index with no change in adiposity as compared to MV. Serum TAG levels were increased in MV group (222±19 mg/dL) compared to CV (145±21 mg/dL) and MP group (212±19 mg/dL) did not show significant difference compared to MV. Fat liver deposition markedly increased in MV group when compared to CV, and decreased in MP group in relation to MV. Treatment with pterostilbene increased TAG‐hydrolytic activity in the liver of control and obese groups. In addition, SIRT‐1 mRNA expression increased in MP when compared to MV. Our data clearly established that the treatment of obese rats with pterostilbene has beneficial effects in the reduction of liver fat deposition by increasing TAG‐hydrolytic activity, probably by SIRT‐1 pathway.Grant Funding Source: Supported by CNPq, CAPES, FAPEMIG