Abstract
Introduction & Objectives: The diagnostic pathway for prostate cancer (PCa) is advancing towards an imaging-driven approach. The introduction of new ultrasound (US) modalities, such as quantitative contrast-enhanced US (CEUS), shear wave elastography (SWE) and the combination of different US modalities shows promise but a structured comparison with gold standard radical prostatectomy (RP) specimens is still lacking. The primary objective of this study is to determine the diagnostic performance of greyscale US (GS), SWE, CEUS and their combination, multiparametric US (mpUS) for the detection and localization of clinically significant (cs)PCa by comparison with corresponding RP histopathology.
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